THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS

Aysel SARI¹ , Ala[INJ]in ÇUKUROVALI²

Thiosemicarbazones (TSC) are a class of compounds very promising in the treatment of many diseases, cancer in particular, and its development is still in progress. The purpose of the present study was to evaluate the effect of 1-(1-phenil-1-methylcyclobutane-3-yl)-2-suksinimido etanonthiosemicarbazone (FSTSC) on antioxidan vitamins (A, E, C) in liver, kidney and serum of rabbits. Twenty male rabbits were randomly divided into two groups. The first group was used as a control which injected subcutaneously of 250µl, 10% dimethylsulphoxide was given to the control group every otherday. FSTSC compound (25mgkg–1, dissolved in 250µl, 10% dimethylsulphoxide) was administered to the other group of rabbits.This administration was done for a period of 32days.The vitamin levels (A, E and C) were determined by high performance liquid chromatography (HPLC). The liver tissue and serum vitamin C levels were significantly decreased compared to control group (P<0.05). Levels of vitamins A in kidney was significantly decreased compared to control group (P<0.05). In addition to many pharmacological properties of the TSC derivatives examined, it will contribute to the knowledge of the literature.

Keywords
Thiosemicarbazone, Antioxidants, Liver, Kidney, Serum, Rabbit, HPLC,