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Article Details

  • Article Code : NWSA-10979-4503
  • Article Type : Araştırma Makalesi
  • Publication Number : 3A0068
  • Page Number : 14-20
  • Doi : 10.12739/NWSA.2015.10.2.3A0068
  • Abstract Reading : 972
  • Download : 133
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Issue Details

  • Year : 2015
  • Volume : 10
  • Issue : 2
  • Number of Articles Published : 4
  • Published Date : 1.04.2015

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Physical Sciences

Serial Number : 3A
ISSN No. : 1308-7304
Release Interval (in a Year) : 4 Issues

5,5`-BÜTAN-1,4-DIILBIS [4-ALLIL-2-({4-[3 (TRIFLOROMETIL) FENIL] PIPERAZIN-1-IL} METIL)-2,4-DIHIDRO-3H-1,2,4-TRIAZOL-3-TIYON BİLEŞİĞİNİN FARELERİN BÖBREK, KARACİĞER VE SERUMLARINDAKİ MDA VE VİTAMİN DÜZEYLERİNE ETKİSİ

Naci Ömer Alayunt 1 , Sait Çelik 2 , Metin KOPARIR 3 , Mustafa KARATEPE4

1,2,4-triazol türevleri çeşitli farmakolojik aktivite gösterdikleri bilinmektedir. flukonazol, intraconazole, vorikonazol gibi 1,2,4-triazol türevleri içeren kısımlar çeşitli uyuşturucu ve terapötik ilaçlar da dahil olmak üzere anti-enflamatuar, CNS uyarıcılar, yatıştırıcılar, sakinleştirici maddeler, antibiyotik antimikotik etkilere sahiptir. Kullanılan aminometil türevi daha önce bildirildiği gibi yeniden sentezlendi. Bu çalışmada, yeni sentezlenmiş bis-1,2,4-triazol içeren aminometil türevi bileşik rat serum, karaciğer ve böbrek dokularında malondialdehit(MDA)ve antioksidan vitamin (A,E,C)düzeyleri incelendi. Malondialdehit düzeyi (MDA) ve vitaminler (A,E,C) HPLC cihazı kullanılarak belirlendi. L bileşiği kontrol ile karşılaştırıldığında iyi aktivite gösterdiği belirlendi.

Keywords
1,2,4-Triazol, Aminometil Türevi, Vitamin, Serum, Karaciğer, Böbrek, Fare,

THE EFFECTS OF 5,5`-BUTANE-1,4-DIYLBIS [4-ALLYL-2-({4-[3-(TRIFLUOROMETHYL) PHENYL] PIPERAZIN-1-YL} METHYL)- 2,4-DIHYDRO-3H-1,2,4-TRIAZOLE-3-THIONE] COMPOUND ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS

Naci Ömer Alayunt 1 , Sait Çelik 2 , Metin KOPARIR 3 , Mustafa KARATEPE4

The 1,2,4-triazole along with its derivatives were reported to exhibit various pharmacological activities [1]. 1,2,4-triazole moieties have been incorporated into a wide variety of therapeutically interesting drug candidates, including anti-inflammatories, CNS stimulants, sedatives, anti-anxiety compounds, antimicrobial agents, as well as anti-mycotic ones such as fluconazole, intraconazole andvoriconazole [2]. As previously reported, Aminomethyl derivatives were synthesized. In this study, the effects of newly synthesized bis-1,2,4-triazole containing aminomethyl derivatives on the level of malondialdehyde(MDA)and antioxidant vitamins (A,E,C) of the serum, liver and kidney of rats have been investigated. In addition, level of malondialdehyde (MDA) and vitamins (A,E,C) has been determined by HPLC [3]. Most of the compounds showed satisfactory performance when compared to the control group [4].

Keywords
1,2,4-Triazole, Aminomethyl Derivative, Vitamin, Serum, Kidney, Liver, Rat,

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Authors

Naci Ömer Alayunt (1) (Corresponding Author)

nacialayunt@hotmail.com

Sait Çelik (2)

saitelik75@gmail.com

Metin KOPARIR (3)

Fırat Üniversitesi
mkoparir@hotmail.com

Mustafa KARATEPE (4)

Fırat Üniversitesi
mkaratepe23@yahoo.com | 0000-0001-6358-5913

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