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Article Details

Article Details

  • Article Code : NWSA-779-503
  • Article Type : Araştırma Makalesi
  • Publication Number : 5A0012
  • Page Number : 86-96
  • Doi : 10.12739/
  • Abstract Reading : 1121
  • Download : 134
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Issue Details

  • Year : 2009
  • Volume : 4
  • Issue : 2
  • Number of Articles Published : 9
  • Published Date : 1.04.2009

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Dergi Kapağı
Ecological Life Sciences

Serial Number : 5A
ISSN No. : 1308-7258
Release Interval (in a Year) : 4 Issues

7,12-DMBA UYGULANAN YAŞLI RATLARIN KARACİĞER VE BÖBREK DOKULARINDAKİ YAĞ ASİDİ BİLEŞİMİNE RESVERATROL VE ?-LİPOİK ASİDİN ETKİLERİNİN İNCELENMESİ

Muammer BAHŞİ 1

Bu çalışmada Resveratrol ve ?-Lipoik asidin 7,12-DMBA uygulanan yaşlı ratların karaciğer ve böbrek dokularındaki yağ asidi kompozisyonu üzerine düzenleyici etkileri araştırıldı. Ratlar, kontrol, DMBA, DMBA+?-LA ve DMBA+R olarak rastgele gruplara ayrıldı. GC kullanılarak yağ asidi içeriğine olan faydalı etkileri araştırıldı. Gaz kromatografi analiz sonuçlarına göre, palmitik asit (16:0) düzeyinin karaciğer dokusunda kontrol grubuna göre yüksek bulundu (p<0.001). Karaciğerde stearik asit düzeyinin DMBA (p<0.01) ve DMBA+?-LA (p<0.05) gruplarında arttığı tespit edildi. Karaciğer dokusunda linoleik asidin (18:2 n–6) DMBA ve DMBA+R gruplarında (p<0.05) azaldığı belirlendi. Araşidonik asit (20:4 n–6) düzeyinin böbrek dokusunda DMBA grubunda arttığı (p<0.05) tespit edildi (p<0.05). Tüm dokularda dokosaheksaenoik asit (22.6 n–3) düzeyinin arttığı saptandı.

Keywords
7,12-DMBA, Resveratrol, ALFA Lipoik Asit, GC , Yaşlı Sıçanlar,

THE EXAMINATON OF THE EFFECTS OF RESVERATROL AND ?-LIPOIC ACID ON FATTY ACID COMPOUNDS IN LIVER AND KIDNEY TISSUES OF OLD RATS INDUCED BY 7,12-DMBA

Muammer BAHŞİ 1

In this study, the regulator effects of resveratrol and alpha-lipoic acid on fatty acid compositions on 7.12-DMBA-induced old male rat’s liver and kidneys were investigated. The rats divided randomly groups as control, DMBA, DMBA+LA and DMBA+R. Fatty acid content were analyzed by using GC in order to determine the benefit effects of these antioxidant against by 7,12-DMBA-induced oxidative stress in wistar rats. According to gas chromatography results, it is found that rations of palmitic acid (16:0) in liver tissues of disease group were higher than control group (p<0.001). The ratio of stearic acid (18:0) was increased in liver DMBA (p<0.01). Also the ratio of linoleic acid (18:2 n-6) was decreased in liver DMBA and DMBA+R groups (p<0.05). However, for the ratio of arachidonic acid(20:4 n–6), in the DMBA group of the kidney tissue was increased (p<0.05). Consequently, the ratio of docosahexaenoic acid (22:6 n–3) was raised in all kinds of tissues.

Keywords
7,12-DMBA, Resveratrol, ALFA Lipoic Acid, GC , Aged Rats,

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Muammer BAHŞİ (1) (Corresponding Author)
Fırat Üniversitesi
muammerbahsi@hotmail.com

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