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Article Details

  • Article Code : FIRAT-AKADEMI-3093-5819
  • Article Type : Araştırma Makalesi
  • Publication Number : 5A0246
  • Page Number : 46-53
  • Doi : 10.12739/NWSA.2026.21.2.5A0246
  • Abstract Reading : 23
  • Download : 7
  • Atıf Sayısı : 0
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Issue Details

  • Year : 2026
  • Volume : 21
  • Issue : 2
  • Number of Articles Published : 1
  • Published Date : 1.04.2026

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Dergi Kapağı
Ecological Life Sciences

Serial Number : 5A
ISSN No. : 1308-7258
Release Interval (in a Year) : 4 Issues

KAFEIK ASIT FENETİL ESTER (CAPE) VE 10-HİDROKSİ-2-DEKANOİK ASİT (10-HDA) UYGULANAN ZEBRA BALIĞI (Danio rerio)’ NDA BAZI BÜYÜME PARAMETRELERININ BELIRLENMESI

M. Enis YONAR 1 , Serpil Mise Yonar 2 , Feyza Karahüseyinoğlu3

Balıklarda büyüme hem doğal stokların sürdürülebilirliği hem de akuakültür verimliliği için kritik bir biyolojik süreçtir. Bu çalışma, zebra balığında kafeik asit fenetil ester (CAPE) ve 10-hidroksi-2-dekanoik asit (10-HDA) kullanımının büyüme performansı üzerindeki etkilerini araştırmak amacıyla planlanmıştır. Denemede; kontrol, CAPE, 10-HDA ve CAPE + 10-HDA olmak üzere dört grup oluşturulmuştur. Söz konusu bileşikler, ticari yem içerisine 10 mg/kg dozunda eklenerek 8 hafta boyunca uygulanmıştır. Balıklar günde dört öğün, canlı ağırlıklarının %5'i oranında beslenmiş; performans değerlendirmeleri canlı ağırlık artışı ve spesifik büyüme oranı üzerinden yapılmıştır. Deneme sonunda tüm gruplarda ağırlık artışı gözlense de, gruplar arasında istatistiksel olarak anlamlı bir farklılık tespit edilmemiştir. Sonuç olarak, CAPE ve 10-HDA uygulamalarının büyüme performansını kontrol grubuna benzer düzeyde etkilediği ve canlı ağırlık artışı üzerinde anlamlı bir etkisinin olmadığı belirlenmiştir.

Keywords
10-hidroksi-2-dekanoik asit, Kafeik Asit Fenetilester, Büyüme, Zebra Balığı, Akuakültür,

DETERMINATION OF SOME GROWTH PARAMETERS IN ZEBRAFISH (Danio rerio) TREATED WITH CAFFEIC ACID PHENETHYL ESTER (CAPE) AND 10-HYDROXY-2-DECANOIC ACID (10-HDA)

M. Enis YONAR 1 , Serpil Mise Yonar 2 , Feyza Karahüseyinoğlu3

Fish growth is a critical biological process for both the sustainability of wild stocks and aquaculture productivity. This study was designed to investigate the effects of caffeic acid phenethyl ester (CAPE) and 10-hydroxy-2-decanoic acid (10-HDA) on growth performance in zebrafish. In the experiment, four groups were established: control, CAPE, 10-HDA, and CAPE + 10-HDA. The compounds were added to commercial feed at a dose of 10 mg/kg and administered for 8 weeks. The fish were fed four times daily at a rate of 5% of their live weight; performance evaluations were based on live weight gain and specific growth rate. Although weight gain was observed in all groups at the end of the experiment, no statistically significant differences were detected between the groups. As a result, it was determined that the administration of CAPE and 10-HDA affected growth performance at a level similar to the control group and had no significant effect on live weight gain.

Keywords
10-Hydroxy-2-decanoic acid, Caffeic Acid Phenethyl Ester, Growth, Zebrafish, Aquaculture,

Details
   

Authors

M. Enis YONAR (1) (Corresponding Author)
Fırat Üniversitesi
meyonar@gmail.com | 0000-0001-9519-4247

Serpil Mise Yonar (2)

serpilmise@gmail.com

Feyza Karahüseyinoğlu (3)

Fırat Üniversitesi
feyzakara8684@gmail.com | 0009-0008-0751-8036

Supporting Institution

 :

Project Number

 : SÜF.25.07

Thanks

 : Bu çalışma[INJ] Fırat Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi [INJ]FÜBAP[INJ] tarafından SÜF.25.07 numaralı proje kapsamında desteklenmiştir. Sağlanan katkı ve desteklerinden dolayı FÜBAP birimine teşekkür ederiz.
References
1. Triantaphyllopoulos, K., Cartas, D., and Miliou, H., (2019). Factors influencing GH and IGF-I gene expression on growth in teleost fish. Reviews in Aquaculture, 12:1637-1662.

2. Pérez-Sánchez, J., Simó-Mirabet, P., Naya-Català, F., Martos-Sitcha, J., Perera, E., Bermejo-Nogales, A., Benedito-Palos, L. and Calduch-Giner, J., (2018). Somatotropic axis regulation in fish growth. Frontiers in Endocrinology, 9.

3. El-Hack, M., El-Saadony, M., Nader, M., Salem, H., El-Tahan, A., Soliman, S., and Khafaga, A., (2022). Effect of environmental factors on growth performance of Nile tilapia (Oreochromis niloticus). International Journal of Biometeorology, 66:2183-2194. DOI:10.1007/s00484-022-02347-6.

4. Li, L., Shen, Y., Yang, W., Xu, X., and Li, J., (2021). Effect of different stocking densities on fish growth performance: A meta-analysis. Aquaculture, 544: 737152.

5. Haetami, K. and Pratiwy, F., (2023). Relationship between feeding regime and fish growth. Asian Journal of Fisheries and Aquatic Research. DOI:10.9734/ajfar/2023/v24i2631.

6. Pickering, A., (1993). Growth and stress in fish production. Aquaculture, 111:51-63.

7. Canosa, L. and Bertucci, J., (2023). The effect of environmental stressors on growth in fish and its endocrine control. Frontiers in Endocrinology, 14. DOI: 10.3389/fendo.2023.1109461.

8. Oliva-Teles, A., (2012). Nutrition and health of aquaculture fish. Journal of Fish Diseases, 35(2):83-108.

9. Valente, L., Moutou, K., Conceição, L., Engrola, S., Fernandes, J., and Johnston, I., (2013). Growth potential and juvenile quality of farmed fish. Reviews in Aquaculture, 5:168-193.

10. Lugert, V., Thaller, G., Tetens, J., Schulz, C., and Krieter, J., (2016). A review on fish growth calculation. Reviews in Aquaculture, 8:30-42. DOI: 10.1111/raq.12071.

11. Soderberg, R., (2017). Factors affecting fish growth and production. DOI: 10.1201/9780203759028-9.

12. Esmaeili, M., (2021). Blood performance: A new formula for fish growth and health. Biology, 10. DOI: 10.3390/biology10121236.

13. Dutta, H., (1994). Growth in fishes. Gerontology, 40(2-4):97-112.

14. Chakraborty, A., Begum, N., Anam, U., Gupta, T., Iqbal, M., and Hossain, M., (2025). Growth factors and condition indices of some air-breathing and catfishes from Hakaluki Haor, Bangladesh. Journal of Applied Ichthyology. DOI: 10.1155/jai/7463844.

15. Carvalho, A.A., Finger, D., Machado, C.S., Schmidt, E.M., Costa, P.M., Alves, A.P.N.N., and Torres, Y.R., (2011). In vivo antitumoural activity and composition of an oil extract of Brazilian propolis. Food Chemistry, 126:1239.

16. Murtaza, G., Karim, S., Akram, M., Khan, S., Azhar, S., Mumtaz, A., and Asad, M., (2014). Caffeic acid phenethyl ester and therapeutic potentials. BioMed Research International, 2014: 145342. DOI: 10.1155/2014/145342.

17. Sudina, G.F., Mirzoeva, O.K., Pushkareva, G.A., Sumbatyan, N.V., and Varfolomeev, S.D., (1993). CAPE as a lipoxygenase inhibitor. FEBS Letters, 329(1-2):21-24.

18. Russo, A., Longo, R., and Vanella, A., (2002). Antioxidant activity of propolis. Fitoterapia, 73:21-29.

19. Yis, U., Topcu, Y., Ozbal, S., Tugyan, K., Bayram, E., Karakaya, P., Yilmaz, O., and Kurul, S.H., (2013). CAPE prevents apoptotic cell death. Epilepsy and Behaviour, 29(2):275-280.

20. Genç, M. and Aslan, A., (1999). Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography. Journal of Chromatography A, 839(1-2):265-268.

21. Peng, C.C., Sun, H.T., Lin, I.P., Kuo, P.C., and Li, J.C., (2017). Functional property of royal jelly. BMC Complementary and Alternative Medicine, 17:392.

22. Collazo, N., Carpena, M., Nuñez-Estevez, B., Otero, P., Simal-Gandara, J., and Prieto, M.A., (2021). Health promoting properties of bee royal jelly: Food of the queens. Nutrients, 13(2):543.

23. Nakajima, Y., Tsuruma, K., Shimazawa, M., Mishima, S., and Hara, H., (2009). Comparison of bee products based on antioxidant capacities. BMC Complementary and Alternative Medicine, 9:4.

24. Çelikkale, M.S., (1988). İçsu balıkları ve yetiştiriciliği. Trabzon: Karadeniz Teknik Üniversitesi.

25. Halver, J.E., (1989). Fish Nutrition (2. baskı). San Diego: Academic Press.

26. Ji, S., Song, L., Tian, Z., Wei, M., Ji, H., and Sun, J., (2025). Caffeic acid phenethyl ester improves high-carbohydrate diet utilization. Animal Nutrition, 22: 154-164. DOI: 10.1016/j.aninu.2025.03.009.

27. Li, H., Ji, S., Song, L., Wei, M., Tian, Z., Ji, H. ve Sun, J., (2025). Caffeic acid phenethyl ester promotes adipocyte hyperplasia. Aquaculture. DOI: 10.1016/j.aquaculture.2025.742201.

28. Vural, O., Silici, S., andAksakal, E., (2021). Effect of royal jelly dietary on zebrafish. Aquaculture Reports.

29. Han, L., Zhang, M., Li, F., Su, J., Wang, R., Li, G., and Yang, X., (2023). 10-hydroxy-2-decenoic acid alleviates lipopolysaccharide-induced intestinal mucosal injury. Frontiers in Microbiology, 14. DOI: 10.3389/fmicb.2023.1285299.

30. Zhang, Y., Geng, S., Di, Y., Sun, Y., Liu, Y., Li, J., and Zhang, L., (2022). 10-hydroxy-trans-2-decenoic acid as feed additive. Animals, 12. DOI: 10.3390/ani12141846.

31. Alrashada, Y., Hassanien, H., Abbas, A., Alkhamis, S., and Alkobaby, A., (2023). Dietary propolis improves the growth performance, redox status, and immune response of Nile tilapia upon a cold-stress challenge. PLOS ONE, 18. DOI: 10.1371/journal.pone.0293727.

32. Ismail, T. and Hegazi, E., (2025). Propolis as a growth stimulant for Nile tilapia (Oreochromis niloticus) juveniles. Journal of Animal Physiology and Animal Nutrition.

33. Mustafa, A., Al-Gburi, M., Mustafa, S., and Researcher, A., (2025). Efficacy of propolis as feed additives on growth. Iraqi Journal of Agricultural Sciences. DOI: 10.36103/16ng3p27.

34. Farag, M., Abdelnour, S., Patra, A., Dhama, K., Dawood, M., Elnesr, S., and Alagawany, M., (2021). Propolis: Properties and composition, health benefits and applications in fish nutrition. Fish & Shellfish Immunology. DOI: 10.1016/j.fsi.2021.06.010.

35. Lin, M., Guo, X., Xu, X., Chang, C., Le, T., Cai, H., and Zhao, M., (2025). Caffeic acid phenethyl ester alleviates alcohol-induced inflammation. Biomolecules, 15.