GENOTOXIC EFFECTS OF SOME FOOD ADDITIVES ON MAMMALS

PINAR AKSU KILIÇLE¹ , Özlem ÖNEN²

Food additives are substances that are added to foods for many purposes such as prevention of microbiological deterioration and increase of durability, nutritive value preservation, assisting technological operations, correction of sensory characteristics such as color, appearance, taste, smell. In this review, it is aimed to summarize the data on the genotoxic effects of the various food additives on the mammals and to provide a source for further work to be done thereafter. It has been reported that food additives cause genotoxicity compared to the results obtained from studies using various genotoxicity tests. In vivo and in vitro studies, it has been determined that additives increase genotoxicity and cytotoxicity depending on the applied dose. As a result; in this review, various in vivo and in vitro studies have shown that exposure to food additives is both genotoxic and cytotoxic on mammals, where findings are generally parallel to each other as a result of assessed studies.

Keywords
Food Preservatives, Mammals, Genotoxic Effect, Microbiological Deterioration, Cytotoxicity ,