CEREBROSPINAL FLUID (CSF) IL-17A, IL-17F, IL-34 AND CXCL-13 LEVELS IN AMYOTROPHIC LATERAL SCLEROSIS (ALS/MND) PATIENTS

Hayriye SOYTÜRK¹ , Şeyda KARABÖCEK² , Bihter Gökçe BOZAT³ , Şule AYDIN TÜRKOĞLU⁴

In this study, our clinic follow-up ALS/MND diagnose the cerebrospinal fluid of patients (CSF), IL-17A, IL-17F, IL-34 cytokines and CXCL-13 chemokine to evaluate the levels. that were determined by ELISA. In our study, significantly higher in the patient group and the proinflammatory cytokine, IL-17A and IL-17F of endothelial cells, fibroblasts and also known to be expressed in neurones. However, CXCL-13 level is considered among the patient group and the control group was not statistically significant difference. IL-34 also to be increased when compared to the patient group (n=4) than the control group (n=6), a recently described cytokine due to the IL-34 Th17 with modulating immune pathogenesis and immune with cytokines released from cells in a short time to be involved ALS/MND such as rare as to be made further studies for the diagnosis of a disease to a powerful new biomarker may and science has been suggested to contribute in this respect.

Keywords
ALS/MND, IL-17, IL-34, CXCL-13, Patient,