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Article Details

Article Details

Issue Details

  • Year : 2023
  • Volume : 18
  • Issue : 2
  • Number of Articles Published : 4
  • Published Date : 1.04.2023

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Dergi Kapağı
Ecological Life Sciences

Serial Number : 5A
ISSN No. : 1308-7258
Release Interval (in a Year) : 4 Issues

SALVIA OFFICINALIS’İN ANTİOKSİDAN VE ANTİMİKROBİYAL AKTİVİTELERİ ÜZERİNE YAPILAN ÇALIŞMALARIN SİSTEMATİK DEĞERLENDİRİLMESİ

Didem VEREP1 , Saim ATEŞ2

Halk hekimliği, bitkilerden elde edilen özütlerin yaraların iyileştirilmesinde ve hastalıkların önlenmesi ya da tedavi edilmesi için kullanılmasıyla hayatımıza girmiştir. Antioksidan ve antimikrobiyal aktivitedeki bitkiler anti-fungal, anti-helmintik, tıbbi amaçlı ve yoğun olarak gıdalarda koruyucu olarak kullanılmaktadır. Geçmişten günümüze kadar tedavi amaçlı kullanımı, fenolik bileşenlerce zengin olması ve birçok araştırmaya konu olması sebebiyle derleme çalışması için Salvia officinalis bitkisi tercih edilmiştir. Bu derleme çalışmasında; Salvia officinalis’in geleneksel tıbbi yönleri ile antioksidan ve antimikrobiyal aktivitesi bakımından farmakolojik özellikleri incelenmiştir. Salvia officinalis bitkisinden elde edilen ekstrakt ya da uçucu yağların sentetik antioksidanlar veya antimikrobiyal ajanlar yerine kullanımının artırılması ve suni ürünlere alternatif doğal ürünlerin endüstrileştirilmesi konusunda yüksek potansiyelde olduğu çalışmaların değerlendirilmesiyle belirlenmiştir.

Keywords
Salvia officinalis, Tıbbi Bitkiler, Farmakoloji, Antioksidan, Antimikrobiyal,

SYSTEMATIC EVALUATION OF STUDIES ON THE ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF SALVIA OFFICINALIS

Didem VEREP1 , Saim ATEŞ2

Folk medicine has entered our lives with the use of extracts from plants to heal wounds and to prevent or treat diseases. Plants with antioxidant and antimicrobial activity are used for anti-fungal, anti-helminthic, medicinal purposes and extensively as preservatives in foods. Salvia officinalis plant was preferred for the review study because it has been used for therapeutic purposes from the past to the present, is rich in phenolic compounds and has been the subject of many studies. In this review study; traditional medicinal aspects of Salvia officinalis and its pharmacological properties in terms of antioxidant and antimicrobial activity were investigated. It has been determined by the evaluation of the studies that the extracts or essential oils obtained from Salvia officinalis have a high potential for increasing the use of synthetic antioxidants or antimicrobial agents instead of synthetic antioxidants or antimicrobial agents and industrialisation of natural products alternative to artificial products.

Keywords
Salvia officinalis, Medicinal Plants, Pharmacology, Antioxidant, Antimicrobial,

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Authors

Didem VEREP (1) (Corresponding Author)
Bingöl Üniversitesi
dverep@bingol.edu.tr | 0000-0002-1013-9212

Saim ATEŞ (2)

saimates@kastamonu.edu.tr | 0000-0003-0589-1773

Supporting Institution

 :

Project Number

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Thanks

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References
[1] Çenet, M. ve Toroğlu, S., (2006). Tedavi amaçlı kullanılan bazı bitkilerin kullanım alanları ve antimikrobiyal aktivitelerinin belirlenmesi için kullanılan metodlar. KSÜ Fen ve Mühendislik Dergisi, 9(2):12-20.

[2] Inoue, M., Hayashi, S., and Lyle, E., (2019). Role of medicinal and aromatic plants: past, present and future. In: Shagufta P, Areej A-T (eds) Pharmacognosy-medicinal plants. IntechOpen, London.

[3] Dönmez, İ. E., Hemming, J., and Willför, S., (2016). Bark extractives and suberin monomers from arbutus andrachne and platanus orientalis. BioResources, 11(1):2809-2819.

[4] Faydaoğlu, E. ve Sürücüoğlu, M., (2013). Tıbbi ve aromatik bitkilerin antimikrobiyal, antioksidan aktiviteleri ve kullanım olanaklar. Ege Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 6(2):233-265.

[5] Farooq, S. ve Ngaini, Z., (2021). Natural and synthetic drugs as potential treatment for coronavirus disease 2019 (COVID-2019). Chemistry Africa, 4:1-13.

[6] Dönmez, İ.E., (2010). Yükselti farkına göre sarıçamın (pinus sylvestris l.) anatomik ve kimyasal bileşiminde meydana gelen değişimler (Doktora Tezi). Bartın: Bartın Üniversitesi Fen Bilimleri Enstitüsü.

[7] Mousavi, S.A., Nateghi, L., Dakheli, M.J., Ramezan, Y., and Piravi-Vanak, Z., (2022). Maceration and ultrasound-assisted methods used for extraction of phenolic compounds and antioxidant activity from ferulago angulata. Journal of Food Processing and Preservation, 46(3):16356.

[8] Agregan, R., Munekata, P.E.S., Feng, X., Astray, G., Gullon, B., and Lorenzo, J.M., (2021). Recent advances in the extraction of polyphenols from eggplant and their application in foods. LWT-Food Science and Technology, 146:111381.

[9] Arias, A., Feijoo, G., and Moreira, M.T., (2022). Exploring the potential of Antioxidants from fruits and vegetables and strategies for their recovery. Innovative Food Science and Emerging Technologies, 77:102974.

[10] Borneo, R., Le´on, A.E., Aguirre, A., Ribotta, P., and Cantero, J.J., (2009). Antioxidant capacity of medicinal plants from the Province of C´ordoba (Argentina) and their in vitro testing in a model food system. Food Chemistry, 112:664–70.

[11] Sharifi-Rad, M., Anil Kumar, N.V., Zucca, P., Varoni, E.M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P.V., Azzini, E., Peluso, I., Prakash, M.A., Nigam, M., El Rayess, Y., Beyrouthy, M.E., Polito, L., Iriti, M., Martins, M., Martorell, M., Docea, A.O., Setzer, W.N., Calina, D., Cho, W.C., and Sharifi-Rad, J., (2020). Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases. Front in Physiology, 11:694.

[12] Loizzo, M.R., Tundis, R., Chandrika, U.G., Abeysekera, A.M., Menichini, F., and Frega, N.G., (2010). Antioxidant and antibacterial activities on foodborne pathogens of Artocarpus heterophyllus Lam (Moraceae) leaves extracts. Journal of Food Science, 75:291–5.

[13] Atanasov, A.G., Zotchev, S.B., and Dirsch, V.M., (2021). Natural products in drug discovery: advances and opportunities. Nature Reviews Drug Discovery, 20:200–216.

[14] Anwar, H., Hussain, G., and Mustafa, I., (2018). Antioxidants from natural sources. In: Shalaby E, Azzam GM (eds) Antioxidants in foods and its applications. IntechOpen, London.

[15] İskefiyeli, Z., (2014). Damlatma ile yeni DPPH ve frap antioksidan tayin yontemlerinin geliştirilmesi ve uygulanması (Doktora Tezi). Trabzon: Karadeniz Teknik Universitesi Fen Bilimleri Enstitüsü.

[16] Şahin, Ö., (2019). Determination of components of extracted from different parts of melocan (smilax excelsa l.) Plant by Microwave and Ultrasonic Assisted Extraction (Yüksek Lisans Tezi). Ankara: Hacettepe Üniversitesi Fen Bilimleri Enstitüsü.

[17] Albayrak, S., Sağdıc, O. ve Aksoy, A., (2010). Bitkisel Urunlerin ve gıdalarin antioksidan kapasitelerinin belirlenmesinde kullanılan yontemler. Erciyes Universitesi Fen Bilimleri Enstitüsü Dergisi, 26:401-409.

[18] Katsube, T., Tsurunaga, Y., Sugiyama, M., Furuno, T., ve Yamasaki, Y., (2009). Effect of air-drying temperature on Antioxidant capacity and stability of polyphenolic compounds in mulberry (Morus alba L.) leaves. Food Chemistry, 113:964-969.

[19] Ares, A.M., Valverde, S., Bernal, J.L., Nozal, M.J., and Bernal, J., (2017). Extraction and Determination of Bioactive Compounds from Bee Pollen. Journal of Pharmaceutical and Biomedical Analysis.

[20] Sekar, S. ve Kandavel, D., (2010). Interaction of plant growth promoting rhizobacteria (PGPR) and endophytes with medicinal plants-New Avenues for Phytochemicals. Journal of Phytology, 2:91-100.

[21] Njume, C., Afolayan, A.J., and Ndip, R.N., (2009). An overview of antimicrobial resistance and the future of medicinal plants in the treatment of Helicobacter pylori Infections. African Journal of Pharmacy and Pharmacology, 3:685-699.

[22] Vital, P.G., Velasco, J.R.N., Demigillo, J.M., and Rivera, W.L., (2010). Antimicrobial activity, cytotoxicity and phytochemical screening of Ficus septica Burm and Sterculia foetida L. leaf extracts. Journal of Medicinal Plants Research, 4:058-063.

[23] Hussain, T., Arshad, M., Khan, S., Satar, H., and Qureshi, M.S., (2011). In Vitro screening of methanol plant extracts for their antibacterial activity. Pakistan Journal of Botany, 43:531-538.

[24] Yarnell, E. and Abascal, K., (2004). The Leading Publisher in Biotechnology. Alternative & Complementary Therapies Part 2, 10(5):277-284.

[25] Shanthi Sree, K.S., Yasodamma, N., and Paramageetham, C.H., (2010). Phytochemical screening and ın vitro antibacterial activity of the methanolic leaf extract: Sebastiania chamaelea Müell. Arg. The Bioscan, 5:173-175.

[26] Mohd Nazri, N.A.A., Ahmat, N., Adnan, A., Syed Mohamad, S.A., and Syaripah Ruzaina, S.A., (2011). In vitro antibacterial and radical scavenging activities of malaysian table salad. African Journal of Biotechnology, 10:5728-5735.

[27] Dash, B.K., Sultana, S., and Sultana, N., (2011). Antibacterial activities of methanol and acetone extracts of Fenugreek (Trigonella foenum) and Coriander (Coriandrum sativum). Life sciences and medicine research, 27:1-8.

[28] Şener, İ., Gür, M., Verep, D., Güney, K., and Altuner, E.M., (2017). Antimicrobial activities and some flavonoids in extracts of some medicinal plants. Indian Journal of Pharmaceutical Education and Research, Vol 51, Jul-Sep.

[29] Palchykov, V.A., Zazharskyi, V.V., Brygadyrenko, V.V., Davydenko, P.O., Kulishenko, O.M., and Borovik, I.V., (2020). Chemical composition and antibacterial effect of ethanolic extract of Buxus sempervirens on cryogenic strains of microorganisms in vitro. Chemical Data Collections, 25:100323.

[30] Mohammed, F.S., Kına, E., Sevindik, M., Doğan, M., and Pehlivan, M., (2021). Antioxidant and antimicrobial activities of ethanol extract of helianthemum salicifolium (cistaceae). Indian Journal of Natural Products and Resources, 12(2):459-462.

[31] Igwillo, U.C., Ola-Adedoyin, A.T., Abdullahi, M.M., and Chukwuemeka, A.E., (2019). A review of opportunities and challenges in conservation and use of medicinal and aromatic plants in Nigeria. International Journal of Advanced Research (IJAR), 7(4):770-778.

[32] Zougagh, S., Belghiti, A., Rochd, T., Zerdani, I., and Mouslim, J., (2019). Medicinal and aromatic plants used in traditional treatment of the Oral pathology: The Ethnobotanical survey in the economic capital Casablanca, Morocco (North Africa). Natural Products and Bioprospecting, 9:35–48.

[33] Lu, Y. and Foo, L.Y., (2002). Polyphenolics of Salvia-a review. Phytochemistry, 59:117-140.

[34] Badiee, P., Nasirzadeh, A.R., and Motaffaf, M., (2012). Comparison of salvia officinalis l. essential oil and antifungal agents against Candida Species. Journal of Pharmaceutical Technology & Drug Research, 1.

[35] de Macedo, L.M., dos Santos, E.M., Militao, L., Tundisi, L.L., Ataide, J.A., Souto, E.B., and Mazzola, P.G., (2020). Rosemary (Rosmarinus officinalis L., Syn Salvia rosmarinus Spenn.) and its topical applications: A Review. Plants, 9, 651.

[36] Uysal, I., Koçer, O., Mohammed, F.S., Lekesiz, Ö., Doğan, M., Şabik, A.E., Sevindik, E., Gerçeker, F.Ö., and Sevindik, M., (2023). Pharmacological and nutritional properties: genus salvia. Advances in Pharmacology and Pharmacy, 11(2):140-155.

[37] Keshavarz, M., Bidmeshkipour, A., Mostafaie, A., Mansouri, K., and Mohammadi-Motlagh, H.R., (2010). Anti-Tumor Activity of Salvia officinalis is due to its anti-angiogenic, anti-migratory and anti-proliferative effects. Cell Journal, 12(4):477-482.

[38] Jafari, B., Jafari Sales, A., Khaneshpour, H., Fatemi, S., Pashazadeh, M., Al-Snafi, A. E. ve Shariat, A. (2020). Antibacterial effects of Thymus vulgaris, Mentha pulegium, Crocus sativus and Salvia officinalis on Pathogenic bacteria: A brief review study based on gram-positive and gram-negative bacteria. Jorjani Biomedicine Journal, 8(3):58-74.

[39] Sharma, Y., Velamuri, R., Fagan, J., and Schaefer, J., (2020). Full-spectrum analysis of bioactive compounds in rosemary (Rosmarinus officinalis L.) as influenced by different extraction methods. Molecules, 25(20):1–21.

[40] Ngo, Y.L., Lau, C.H., and Chua, L.S., (2018). Review on rosmarinic acid extraction, fractionation and its anti-diabetic potential. Food and Chemical Toxicology, 121:687–700.

[41] Keijer, T., Bakker, V., and Slootweg, J.C., (2019). Circular chemistry to enable a circular economy. Nature Chemistry, 11(3):190–195.

[42] Al-Mijalli, S.H., Assaggaf, H., Qasem, A., El-Shemi, A.G., Abdallah, E.M., Mrabti, H.N., and Bouyahya, A., (2022). Antioxidant, antidiabetic and antibacterial potentials and chemical composition of salvia officinalis and mentha suaveolens grown wild in morocco. Hindawi, Advances in Pharmacological and Pharmaceutical Sciences, 10:2844880.

[43] Assaggaf, H.M., Naceiri, M.H., Rajab, B.S., Attar, A.A., Alyamani, R.A., Hamed, M., El Omari, N., El Menyiy, N., Hazzoumi, Z., Benali, T., Al-Mijalli, S.H., Zengin, G., AIDhaheri, Y., Eid, A.H., and Bouyahya, A., (2022). Chemical Analysis and Investigation of Biological Effects of Salvia officinalis Essential Oils at Three Phenological Stages. Molecules, 27:5157.

[44] Ben Khedher, M.R., Ben Khedher, S., Chaieb, I., Tounsi, S., and Hammami, M., (2017). Chemical composition and biological activities of Salvia officinalis essential oil from Tunisia. EXCLI Journal, 16:160-173.

[45] Balciunaitiene, A., Liaudanskas, M., Puzeryte, V., Viskelis, J., Janulis, V., Viskelis, P., Griskonis, E., and Jankauskaite, V., (2022). Eucalyptus globulus and salvia officinalis extracts mediated green synthesis of silver nanoparticles and their application as an antioxidant and antimicrobial agent. Plants, 11:1085.

[46] Pop, A.V., Tofana, M., Socacı, S.A., Pop, C., Rotar, A.M., Nagy, M., and Salanta, L., (2016). Determination of antioxidant capacity and antimicrobial activity of selected salvia species. Bulletin UASVM Food Science and Technology, 73(1).

[47] Bouteldja, R., Doucene, R., Aggad, H., Abdi, F.Z., Belkhodja, H., Abdali, M., Zidane, K., and Abaid, S., (2021). Phytochemical characterization, antioxidant and antibacterial activity of Salvia officinalis (L.) extracts from the Tiaret region. European Journal of Biological Research, 11(3):356-366.

[48] Khiya, Z., Hayani, M., Gamar, A., Kharchouf, S., Amine, S., Berrekhis, F., Bouzoubae, A., Zair, T., and El Hilali, F., (2019). Valorization of the Salvia officinalis L. of the Morocco bioactive extracts: Phytochemistry, antioxidant activity and corrosion inhibition. Journal of King Saud University-Science, 31:322-335.

[49] Pavic, V., Jakovljevic, M., Molnar, M., and Jokic, S., (2019). Extraction of Carnosic Acid and Carnosol from Sage (Salvia officinalis L.) leaves by supercritical fluid extraction and their antioxidant and antibacterial activity. Plants, 8, 16.

[50] Wali, A.F., Hamad, E.A., Khazandar, A.A., Al-Azzawi, A.M., Sarheed, A., Menezes, G.A., and Alam, A., (2019). Antimicrobial and in vitro Antioxidant activity of Salvia officinalis L. against various re-emergent multidrug resistance microbial pathogens. Annals of Phytomedicine, 8(2):115-120.

[51] Farahpour, M.R., Pirkhezr, E., Ashrafian, A., and Sonboli, A., (2020). Accelerated Healing by Topical Administration of Salvia officinalis Essential Oil on Pseudomonas Aeruginosa and Staphylococcus Aureus InfectedWound Model. Biomed. Pharmacother. Biomed. Pharmacother, 128, 110120.

[52] Güzel, S., Özay, Y., Kumaş, M., Uzun, C., Özkorkmaz, E.G., Yıldırım, Z., Ülger, M., Güler, G., Çelik, A., Çamlıca, Y., and Kahraman, A., (2019). Wound Healing Properties, Antimicrobial and Antioxidant Activities of Salvia Kronenburgii Rech. f. and Salvia Euphratica Montbret, Aucher & Rech. f. Var. Euphratica on Excision and Incision Wound Models in Diabetic Rats. Biomed. Pharmacother. Biomed. Pharmacother, 111:1260–1276.

[53] Nakiboğlu, M. ve Otan, H., (1992). Tıbbi bitkilerin flavonoidleri. Anadolu Journal of AARI, 4(1):70-93.