THE EFFECTS OF 5,5`-BUTANE-1,4-DIYLBIS [4-ALLYL-2-({4-[3-(TRIFLUOROMETHYL) PHENYL] PIPERAZIN-1-YL} METHYL)- 2,4-DIHYDRO-3H-1,2,4-TRIAZOLE-3-THIONE] COMPOUND ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS

Naci Ömer Alayunt ¹ , Sait Çelik ² , Metin KOPARIR ³ , Mustafa KARATEPE⁴

The 1,2,4-triazole along with its derivatives were reported to exhibit various pharmacological activities [1]. 1,2,4-triazole moieties have been incorporated into a wide variety of therapeutically interesting drug candidates, including anti-inflammatories, CNS stimulants, sedatives, anti-anxiety compounds, antimicrobial agents, as well as anti-mycotic ones such as fluconazole, intraconazole andvoriconazole [2]. As previously reported, Aminomethyl derivatives were synthesized. In this study, the effects of newly synthesized bis-1,2,4-triazole containing aminomethyl derivatives on the level of malondialdehyde(MDA)and antioxidant vitamins (A,E,C) of the serum, liver and kidney of rats have been investigated. In addition, level of malondialdehyde (MDA) and vitamins (A,E,C) has been determined by HPLC [3]. Most of the compounds showed satisfactory performance when compared to the control group [4].

Keywords
1,2,4-Triazole, Aminomethyl Derivative, Vitamin, Serum, Kidney, Liver, Rat,