INVESTIGATION OF THE THERAPEUTIC AND PROTECTIVE EFFECTS OF ATP SENSITIVE POTASSIUM CHANNEL (KATP) AGONISTS AND ANTAGONISTS ON PENICILLIN INDUCED EXPERIMENTAL EPILEPSY MODELS IN RATS

Hayriye SOYTÜRK¹ , Şerif Demir ² , Ömer Bozdoğan ³

Epilepsy is a disease occurring because of extreme activation of nervous system. Increased glutamate and Ca++ in brain is another reason of epilepsy. In this study, we investigated the effects of ATP sensitive potassium channel (KATP) agonists and antagonists on penicillin induced epileptiform activity in male wistar albino rats. Rats were divided three experimental main groups; (1) Control, (2) Before seizures (BS) groups, (3) During seizure (DS) groups. DS and BS groups are divided into four subgroups; (a)5HD, (b)HMR1098, (c)Bepridil (d)P 1075. Bepridil and p1075, reduce the number of spike-waves, while the effect of Bepridil appears to have a similar effect when administered both during and before the seizure. HMR1098 and 5-HD both increased the seizures both when administered before or during the seizure, different from the other studies. When K ATP channel agonists are administered before and during the seizure, they reduce the seizures, while antagonists increase the seizure.

Keywords
Epilepsy, mito KATP, sarc KATP, 5-HD, HMR 1098,