INVESTIGATION OF PHYSIOLOGICAL ROLE OF MITOCHONDRIAL KATP CHANNEL’S ON PENICILLIN G INDUCED EXPERIMENTAL EPILEPSY MODEL IN RATS

Hayriye SOYTÜRK¹ , Şerif Demir ² , Ömer Bozdoğan ³

Epilepsy is one of the neurological diseases that is commonly seen in the world. It is characterized by excessive activation of neurons that can not be controlled by the central nervous system. ATP dependent potassium (KATP) channel modulation is related with the epilepsy. This study is intended to research the physiological role of mitochondrial KATP channels in epilepsy in electrophysiological perspective. And bepridil has been used for this purpose. Wistar albino rats have been used. Animals have been divided into three main groups; Control, bepridil applied groups in pre-seizure, and during seizure. As a result, bepridil once applied prior to seizure in 0.1 and 1mg/kg doses increased the latency period of the seizure. Bepridil showed anticonvulsant effect at doses of 0.1 and 1 mg/kg before and during seizure groups. Closure of sarcoplasmic channels and opening of mitochondrial channels may be important to decrease the convultion occurred during epilepy.

Keywords
Epilepsy, Electrophysiology, KATP, Bepridil, Mito KATP Channel ,