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Article Details

  • Article Code : FIRAT-AKADEMI-6842-4348
  • Article Type : Araştırma Makalesi
  • Publication Number : 3A0083
  • Page Number : 24-30
  • Doi : 10.12739/NWSA.2018.13.2.3A0083
  • Abstract Reading : 618
  • Download : 138
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Issue Details

  • Year : 2018
  • Volume : 13
  • Issue : 2
  • Number of Articles Published : 3
  • Published Date : 1.04.2018

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Physical Sciences

Serial Number : 3A
ISSN No. : 1308-7304
Release Interval (in a Year) : 4 Issues

HİDROKSİÜRE TÜREVİ SCHİFF BAZI METAL KOMPLEKSLERİNİN ANTİMİKROBİYAL ÖZELLİKLERİNİN ARAŞTIRILMASI

Hafize TELÇEKEN1 , Arzu KARATEPE2 , Mehmet ATAŞ3 , Taner DAŞTAN4 , Mustafa KARATEPE5

Schiff bazları epoksidasyon reaksiyonlarında katalizör, iletken polimerlerin eldesinde monomer, antifungal, antibakteriyel, antimikrobiyal ve bazı oksidatif radikal türlerine karşı antioksidan olarak kullanılmaktadır. Son yılllarda, birçok Schiff bazları türevi sentezlenmeye devam edilmektedir. Bu araştırmada, hidroksiüre türevi Schiff bazı Cu (L-Cu), Cd (L-Cd) ve Zn (L-Zn) metal komplekslerinin antimikrobiyal aktiviteleri in vitro olarak araştırıldı. In vitro denemelerde mikrodilüsyon broth metodu uygulandı. Sonuç olarak in vitro çalışmada Hidroksiüre Schiff bazı metal kompleksleri etkili bir antimikrobiyal aktivite göstermiştir.

Keywords
Hidroksiüre, Schiff Bazı, Metal Kompleksi, Antimikrobiyal, Polimer,

THE INVESTIGATION OF ANTIMICROBIAL PROPERTIES IN VITRO OF HYDROXYUREA DERIVATIVE SCHıFF BASE METAL COMPLEXES

Hafize TELÇEKEN1 , Arzu KARATEPE2 , Mehmet ATAŞ3 , Taner DAŞTAN5 , Mustafa KARATEPE5

Schiff bases are used as catalyst in epoxidation reactions, as a monomer in the presence of conductive polymers, as antifungal, antibacterial, antimicrobial, and antioxidant against some oxidative radical species. Recently, many Schiff bases continue to be synthesized. In this study, the effect of the hydroxyurea derivative Schiff base Cu (L-Cu), Cd (L-Cd) and Zn (L-Zn) metal complexes antimicrobial activity was investigated in vitro. Microdilution broth method was applied to in in vitro experiments. As a result, hydroxyurea derivative Schiff base metal complexes showed an effective antimicrobial activity in in vitro study.

Keywords
Hydroxyurea, Schiff Base, Metal Complex, Antimicrobial, Polymer,

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Authors

Hafize TELÇEKEN (1)

hafize_su@hotmail.com | 0000-0003-1267-5307

Arzu KARATEPE (2)

rosence23a@gmail.com | 0000-0003-2791-7980

Mehmet ATAŞ (3)

mehmetatas@cumhuriyet.edu.tr | 0000-0002-9425-0080

Taner DAŞTAN (4)

tanerdastan@cumhuriyet.edu.tr | 0000-0003-0296-6979

Mustafa KARATEPE (5) (Corresponding Author)

Fırat Üniversitesi
mkaratepe23@yahoo.com | 0000-0001-6358-5913

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References
[1] Durackova, Z., Mendiola, M.A., Sevilla, M.T., and Valent, A., (1999). Thiohydrazone Copper (II) Complexes. The Relationship Between Redox Properties and Superoxide Dismutase Mimetic Activity. Bioelectrochemistry and Bioenergetics: 48, 109-116.